A story about learning to cope with loss would be different if the audience was a kindergarten student rather than an adult.
A story about a journey to find one’s self would be different if the genre was comedy rather than horror.
A story about uncovering a hidden truth would be different if it was a book rather than a movie.
A story about a protagonist reconnecting with a former friend would be different if the author wanted the reader to dislike this individual rather than like her or him.
A story about looking for love would be different if the intention was for the reader to agree with the idea of a soulmate rather than disagree.
A story about being judged would be different if the characters were from a higher socio-economic status rather than a lower socio-economic status.